Menthol's Aphrodisiac Qualities Explained?
And More Support for the Involvement of Phenethylamine in Dreams
So, my latest research has brought me to some information which I find VERY interesting. All of these correlations of menthol with an increase in dreams with sexual themes, and that article about peppermint tea being used as an aphrodisiac in Greece, made me interested enough to look around and see if I could find an even better sex dream drug than menthol. At first I started looking more into prolactin-increasing drugs, as like I've said before I believe this is responsible for the sensual/"pure" side of the sex dreams, but I figured there had to be a more direct route to go about it than that. This eventually lead me back to an old interest of mine, yohimbine. Yohimbine has definite aphrodisiac qualities in people (though it can also cause anxiety, which would obviously limit how often those effects might show up in susceptible individuals), but just for the record, to anyone interested, it would make an absolutely atrocious dream drug, as it's a stimulant as well and even directly antagonizes D2 receptors (which blocks the formation of dreams). However, its sexual effects (and thankfully, not its anxiogenic effects) supposedly stem from its antagonism of alpha-2 adrenergic receptors.
The alpha-2 adrenergic receptor is a rather quirky little thing.... It has some seemingly paradoxical effects in the brain and body. Activation of it lowers levels of acetylcholine and catecholamines in the prefrontal cortex, but also causes vasoconstriction in the body and inhibits sexual function (especially erections). This is the exact opposite reaction that would normally be expected from those chemical changes, as vasoconstriction and inhibited function normally accompany the release of dopamine (a major catecholamine), like with stimulants and psychedelics. However, when you think about the fact that dopamine is involved in sexual stimulation, and obviously sexual function is important for sex... it actually makes perfect sense that there's a mechanism like this in the brain. It would also explain why stress, which increases levels of norepinephrine and epinephrine (adrenaline) and activates those receptors, has a negative impact on sex and masturbation. Now, in addition to those functions, activating the receptors also inhibits REM sleep, another bizarre reaction as normally dopaminergic supplements or drugs inhibit REM as well. But again, this makes sense if you consider that stress also weakens dreams. So, as you may have guessed, antagonizing it creates paradoxical effects as well, only in the opposite way... it increases the release of dopamine in the PFC, it causes vasodilation and libido-increasing effects (again, especially erections) in the body, and it enhances REM sleep.
Now, how does this all fit together? Well, think about it.... When you're dreaming, the dopaminergic part of the prefrontal cortex is active in full swing, despite the fact that dopamine normally wakes you up due to its effects on the body. REM sleep is also correlated with increased libido and erections. Lastly, I really hope I don't have to explain the relation to the enhancement of REM phases.... The point is, it is very likely that this blockade or low activity at alpha-2 adrenergic receptors is directly tied into REM sleep. But are you ready for the best part? Really? Do you think you can handle it? Alright, here it comes.... Phenethylamine is an antagonist at alpha-2 adrenergic receptors! Yes, that's right! Not only can phenethylamine explain the generation of dream states, deactivation of the pineal gland, euphoria and lowered inhibition of lucid dreaming, and cessation of motor controls by activating D2 and TAAR1 receptors, but it can in fact even account for the increase in dopaminergic activity and heightened state of libido and correlation with erections that comes with REM sleep!! With all of this in mind, if my theory about kappa-opioid receptors releasing phenethylamine is true, then it means that menthol would be enhancing normal REM libido effects just like it enhances the formation of dreams in general, and it'd be doing it through the same mechanism as yohimbine, a certified aphrodisiac! In fact, I even went scanning through trip reports and posts about salvia use (since it works primarily through kappa-opioid receptors), because this rung a bell... and yes, salvia trips do in fact seem to have a high chance of causing erections. X) And believe me, if you know anything about salvia, you'll know that this is not because the trips are particularly fun or sexy... it's just a physical effect. But in a dream (or any non-horrifying state of mind, unlike salvia) this doesn't apply, and it can definitely make you hornier! And just FYI, I know I keep mentioning erections a lot, but that's just because they're pretty good way to raise a flag (heh) for this type of effect... it applies equally to women.
So what have we learned from all this? Well, assuming that I actually know what the hell I'm talking about... it means that, first of all, a centrally-selective or at least non-stimulant alpha-2 adrenergic receptor antagonist would probably make for an excellent sex dream drug, and second, that menthol may actually have a legitimate reason to have these aphrodisiac qualities through these effects. And believe me, I'm going to find a way to test this out for myself, because this discovery of a potential class of sex dream drugs is far too interesting for me to pass up. 
That's all for now!
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