 Originally Posted by Ne-yo
It's characterized by pseudo relationtionships that would transpire in a likely science fiction novel. There is nothing natural about an event that clearly violates the laws of chemistry.
There isn't, however there is evidence against it. This one is true.
The research says otherwise.
I was asking for a clarification, not childlike condescension.
Why?
I've been mentioning Urey Miller's experiment this entire discussion is this not the modern concept?
Sometimes I get the feeling you don't really know what you're talking about, so I had to clarify.
I could equally post a multitude of papers that shows just the opposite. Look, I'm not saying that one day just maybe one day there could be evidence for it. I'll give you that hope, But we are discussing the concept and where it lies into the realm of validity as of today 2011. So as of today, there is absolutely no evidence for it. Post your papers and we can compare apples to apples and see what comes up.
A Combined Experimental And Theoretical Study On The Formation Of The Amino Acid Glycine And Its Isomer In Extraterrestrial Ices by Philip D. Holtom, Chris J. Bennett, Yoshihiro Osamura, Nigel J Mason and Ralf. I Kaiser, The Astrophysical Journal, 626: 940-952 (20th June 2005) - this paper covers empirical determination of mechanisms required to form the aming acid glycine, under the conditions extant in deep space (specifically, in cometary ices).
A Production Of Amino Acids Under Possible Primitive Earth Conditions by Stanley L. Miller, Science, 117: 528-529 (15th May 1953) - this is THE paper by Stanley Miller, in which he determined that it was possible to form amino acids simply by having electric discharges pass through prebiotic gases.
A Rigorous Attempt To Verify Interstellar Glycine by I. E. Snyder, F. J. Lovas, J. M. Hollis, D. N. Friedel, P. R. Jewell, A. Remijan, V. V. Ilyushin, E. A. Alekseev and S. F. Dyubko, The Astrophysical Journal, 619(2): 914-930 (1st February 2005) {Also available at arXiv.org] - another paper covering the matter of glycine synthesis in interstellar space.
A Self-Replicating Ligase Ribozyme by Natasha Paul & Gerald F. Joyce, Proc. Natl. Acad. Sci. USA., 99(20): 12733-12740 (1st October 2002) - First of many papers covering the existence of sef-replicating short strands of RNA (autocatalytic RNA ribozymes), and analysis of the behaviour thereof.
A Self-Replicating System by T. Tjivuka, P. Ballester and J. Rebek Jr, Journal of the American Chemical Society, 112: 1249-1250 (1990) - demonstration of the existence of autocatalytic organic reactions in other molecules, in this amino-adenosine.
Activated Acetic Acid By Carbon Fixation On (Fe,Ni)S Under Primordial Conditions by Claudia Huber and Günter Wächetershäuser, Science, 276: 245-247 (11th April 1997) - empirical demonstration of the ability of sediments containing certain mineral ions to catalyse organic reactions under the conditions present around deep sea hydrothemral vents, thus allowing for the formation of necessary building blocks under those conditions.
An Asymmetric Underlying Rule In The Assignment Of Codons: Possible Clue To A Quick Early Evolution Of The Genetic Code Via Successive Binary Choices by Marc Delarue, The RNA Journal, 13(2): 161-169 (12th December 2006) - demonstration of the evolvability of the genetic code during the "RNA world" stage, involving assignments of codons based upon specific classes of chemical reaction.
An Expanded Set Of Amino Acid Analogues For The Ribosomal Translation Of Unnatural Peptides by Matthew C. T. Hartman, Kristopher Josephson, Chi-Wang Lin and Jack W. Szostak, PLoS One, 2(10): e972 DOI: 10.1371/journal.pone.0000972 (October 2007) - demonstration that new variations of the genetic code can be produced in vitro, and exotic amino acids incorporated into the genetic code via appropriate chemical manipulation.
Attempted Prebiotic Synthesis Of Pseudouridine by Jason P. Dworkin, Origins of Life and Evolution of the Biosphere, 27: 345-355 (1997) - investigation of the mechanisms of synthesis of pseudouridine, a modified base found in the RNA molecules of a number of modern living organisms.
Autocatalytic Aptazymes Enable Ligand-Dependent Exponential Amplification Of RNA by Bianca J. Lam and Gerald F. Joyce, Nature Biotechnology, 27(3): 288-292 (March 2009) - demonstration that an extended class of RNA molecules can replicate under appropriate conditions, dependent upon the ligands that they react with, and that these can be harnessed for a variety of medical diagnostic applications.
Carbonyl Sulphide-Mediated Prebiotic Formation Of Peptides by Luke Leman, Leslie Orgel and M. Reza Ghadiri, Science, 306: 283-286 (8th October 2004) - demonstration that amino acids can form peptide chains in prebiotic ocean conditions, coutesy of catalysis by carbonyl sulphide, a volcanic gas that is readily soluble in water, and which improves the rate of peptide formation to the extent that 80% yields can be obtained at room temperature in under 24 hours.
Catalysis In Prebiotic Chemistry: Application To The Synthesis Of RNA Oligomers by James P. Ferris, Prakash C. Joshi, K-J Wang, S. Miyakawa and W. Huang, Advances in Space Research, 33: 100-105 (2004) - empirical demosntration in the laboratory that RNA molecules can be synthesised under prebiotic conditions by catalysis on montmorillonite clays, and that under certain conditions, RNA molecules consisting of more than 40 bases can be synthesised catalytically in this manner.
Cations As Mediators Of The Adsorption Of Nucleic Acids On Clay Surfaces In Prebiotic Environments by Marco Franchi, James P. Ferris and Enzo Gallori, Origins of Life and Evolution of the Biosphere, 33: 1-16 (2003) - another empirical demonstration that nucleic acids can be formed by catalytic reactions on montmorillonite clay surfaces under prebiotic ocean conditions.
Chemistry for the Synthesis of Nucleobase-Modified Peptide Nucleic Acid by R. H. E. Hudson, R. D. Viirre, Y. H. Liu, F. Wojciechowski and A. K. Dambenieks, Pure Appl. Chem., 76(7-8) 1591-1598, 2004 - empirical demonstration that alternative nucleic acids exist, and that these could be formed under prebiotic conditions.
Coevolution Of Compositional Protocells And Their Environment by Barak Shenhav, Aia Oz and Doron Lancet, Philosophical Transactions of the Royal Society Part B, 362: 1813-1819 (9th May 2007) - development of a chemically realisable model for protocells, that can be tested via computer simulation in order to determine the likely behaviour of protocells formed via the relevant processes.
Computational Models For The Formation Of Protocell Structures by Linglan Edwards, Yun Peng and James A. Reggia, Artificial Life, 4(1): 61-77 (1998) - computer modelling of lipid self-assembly and its relevance to protocell formation.
Conditions For The Emergence Of Life On The Early Earth: Summary And Reflections by Joshua Jortner, Philosophical Transactions of the Royal Society Part B, 361: 1877-1891 (11th September 2006) - review paper covering the mutliple approaches to the question of the origin of life, from prebiotic chemistry, through to the genetic manipulation of model organisms in the laboratory to create a 'minimal' cell.
Coupled Growth And Division Of Model Protocell Membranes by Ting F. Zhu and Jack W. Szostak, Journal of the American Chemical Society, 131: 5705-5713 (2009) - empirical demonstration of the validity of a model for protocell division without loss of protocell contents, facilitating future research into actual replicating protocells.
Darwinian Evolution On A Chip by Brian M. Paegel and Gerald F. Joyce, Public Library of Science Biology, 6(4): e85 (April 2008) - empirical demonstration that RNa molecule populations undergo Darwinian evolution when subject to relevant chemical selection pressures, in a manner that can be replicated in a well-equipped school laboratory.
Early Anaerobic Metabolisms by Don E Canfield, Minik T Rosing and Christian Bjerrum, Philosophical Transactions of the Royal Society Part B, 361: 1819-1836 (11th September 2006) - demonstration that theories about the metabolic processes of the earliest true cells are consistent with isotopic measurements of extremely ancient strata of the relevant age.
Efficient And Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside-5′-Phosphorimidazolide Monomers by Jason P. Schrum, Alonso Ricardo, Mathangi Krishnamurthy, J. Craig Blain and Jack W. Szostak, Journal of the American Chemical Society, 131(40): 14560-14570 (16th September 2009) - empirical demonstration that encapsulated nucleic acids inside lipid vesicles can replicate, and thus form the basis for model protocells in laboratory investigations.
Emergence Of A Replicating Species From An In Vitro RNA Evolution Reaction by Ronald R. Breaker and Gerald F. Joyce, Proceedings of the National Academy of Sciences of the USA, 91: 6093-6097 (June 1994) - production of a replicating RNA species via in vitro evolution from a population of RNA molecules.
Enzymatic Synthesis Of DNA On Glycerol Nucleic Acid Templates Without Stable Duplex Formation Between Product And Template by Ching-Hsuan Tasi, Jingyang Chen and Jack W. Szostak, Proceedings of the National Academy of Sciences of the USA, 104(37): 14598-14603 (11th September 2007) - demonstration in the laboratory that nucleic acid synthesis using glycerol nucleic acid (GNA) could have provided a pathway from RNA to DNA.
Evolution And Self-Assembly Of Protocells by Ricard V. Solé, The International Journal of Biochemistry & Cell Biology, 41: 274-284 (2009) - demonstration that the protocell formation problem may be easier to solve than previously thought, concentrating upon mechanisms for coupling metabolism and container.
Evolution Of Amino Acid Frequencies In Proteins Over Deep Time: Inferred Order Of Introduction Of Amino Acids Into The Genetic Code by Dawn J. Brooks, Jacques R. Fresco, Arthur M. Lesk and Mona Singh, Molecular and Biological Evolution, 19(10): 1645-1655 (2002) - determination of the likely sequence of insertion of amino acids into the genetic code, based upon analysis of the behaviour of present day transcription systems, and simulations taking into account the differential chemistry of certain classes of amino acid.
Experimental Models Of Primitive Cellular Compartments: Encapsulation, Growth And Division by Martyn M. Hanczyk, Shelley M. Fukijawa and Jack W. Szostak, Science, 302: 618-622 (24th October 2003) - empirical demonstration in the laboratory, that montmorillonite clays catalyse the formation of lipid vesicles from micelles, thus facilitating protocell formation in a prebiotic environment, including the encapsulation of any RNA molecules formed catalytically on the same montmorillonite substrates.
Formation Of Bimolecular Membranes From Lipid Monolayers And A Study Of Their Electrical Properties by M. Montal and P. Mueller, Proceedings of the National Academy of Sciences of the USA, 69(12): 3561-3566 (December 1972) - systematic investigation of the behaviour of lipid bilayers, and how they can be formed from less complex lipd structures.
Formation Of Protocell-Like Structures From Glycine And Formaldehyde In A Modified Sea Medium by Hiroshi Yanagawa and Fujio Egami, Proceedings of the Japan Academy, 53: 42-45 (12th January 1977) - demonstration that structures resembling hypothesised protocells could be produced in prebiotic open oceanic conditions.
Formation Of Protocell-Like Vesicles In A Thermal Diffusion Column by Itay Budin, Raphael J. Bruckner and Jack W. Szostak, Journal of the American Chemical Society, 131: 9628-9629 (2009) - demonstration that thermal diffusion columns associated with hydrothermal vents could have accelerated the formation of protocells.
From Volcanic Origins Of Chemoautotrophic Life To Bacteria, Archaea And Eukarya by Günter Wächtershaüser, Philosophical Transactions of the Royal Society of London Part B, 361: 1787-1808 (7th September 2006) - review paper covering the hypothesis that metabolism of iron and sulphur, as seen in very ancient bacterial and archaeal lineages, could have formed the basis for the modern domains of life.
Functional Information And The Emergence Of Biocomplexity by Robert M. Hazen, Patrick L. Griffin, James M. Carothers and Jack W. Szostak, Proceedings of the National Academy of Sciences of the USA, 104 supplement 1: 8574-8581 (15th May 2007) - demonstration that functional information of the sort needed for the development of metabolisms could have emerged from simpler chemical antecedents.
Generic Darwinian Selection In Catalytic Protocell Assemblies by Andreea Munteanu, Camille Stephan-Otto Attolini, Steen Rasmussen, Hans Ziock and Ricard V. Solé, Philosophical Transactions of the Royal Society Part B, 362: 1847-1855 (2007) - demonstration that several different protocell models of varying initial complexity all undergo Darwinian evolution.
Homochiral Selection In The Montmorillonite-Catalysed And Uncatalysed Prebiotic Synthesis Of RNA by Prakash C. Joshi, Stefan Pitsch and James P. Ferris, Chemical Communications (Royal Society of Chemistry), 2497-2498 (2000) [DOI: 10.1039/b007444f] - demonstration that homochiral synthesis of RNA occurs on montmorillonite clay substrates, resulting in chiral selection for particular enantiomers.
How Life Began On Earth: A Status Report by Jeffrey L. Bada, Earth & Planetary Science Letters, 226: 1-15 (22nd July 2004) - review paper covering a number of relevant abiogenetic hypotheses, and their applicability to the origin of life problem.
Hyperthermophiles In The History Of Life by Karl O. Stetter, Philosophical Transactions of the Royal Society Part B, 361: 1837-1843 (11th September 2006) - demonstration by molecular phylogeny that hyperthermophilic bacteria and archaea are amongst the most ancient of surviving lineages, thus supporting the hypothesis that such organisms were amongst the first true living cells.
Identification Of Diamino Acids In The Murchison Meteorite by Uwe J. Meierhenrich, Guillermo M. Muñoz Caro, Jan Hendrik Brederhöft, Elmar K. Jessberger and Wolfram H-P. Thiemann, Proceedings of the National Academy of Sciences of the USA, 101(25):9182-9286 (22nd June 2004) - determination of the existence of a range of interesting amino acid compounds in a meteorite, supporting the hypothesis that some prebiotic organic molecules could have arrived from space, and assisted the formation of life on Earth.
Implications Of A 3.472-3.333?GYr-Old Subaerial Microbal Mat From The Barberton Greenstone Belt, South Africa, For The UV Environmental Conditions Of The Early Earth by Frances Westall, Cornel E.J de Ronde, Gordon Southam, Nathalie Grassineau, Maggy Colas, Charles Cockell and Helmut Lammer, Philosophical Transactions of the Royal Society Part B, 361: 1857-1876 (11th September 2006) - determination of the existence of microbial fossils, possibly dating back 3.4 billion years, suggesting that conditions for the first living organisms were not as hostile as previously thought.
Information Transfer From Peptide Nucleic Acids To RNA By Template-Directed Syntheses by Jürgen G. Schmidt, Peter E. Nielsen and Leslie E. Orgel, Nucleic Acids Research, 25(23): 4794-4802 (1997) - empirical demonstration in the laboratory that information can be transferred from peptide nucleic acids to RNA, as a possible intermediate step in the formation of the genetic basis of life.
Interstellar Glycine by Yi-Jehng Kuan, Steven B. Charnley, Hui-Chun Huang, Wei-Ling Tseng, and Zbigniew Kisiel, The Astrophysical Journal, 593: 848-867 (20th August 2003) - determination that the amino acid glycine is present in detectable levels in deep interstellar space.
Is There A Common Chemical Model For Life In The Universe? by Steven A. Benner, Alonso Ricardo and Matthew A. Carrigan, Current Opinion in Chemical Biology, 8: 672-689 (22nd October 2004) - proposal that a range of alternative chemistries could also produce 'organisms' that canundergo Darwinian evolution.
Kin Selection And Virulence In The Evolution Of Protocells And Parasites by Steven A. Frank, Proceedings of the Royal Society of London Part B, 258: 153-161 (1994) - demonstration that the existence of 'parasitic' systems can drive the evolution of protocells at an accelerated rate.
Ligation Of The Hairpin Ribozyme In cis Induced By Freezing And Dehydration by Sergei A. Kazakov, Svetlana V. Balatskaya and Brian H. Johnston, The RNA Journal, 12: 446-456 (2006) - demonstration that repeated cycles of freezing and dehydration can drive the formation of RNA molecules, thus allowing for their appearance under cold prebiotic conditions.
Lipid Bilayer Fibres From Diastereomeric And Enantiomeric N-Octylaldonamides by Jürgen-Hinrich Fuhrhop, Peter Schneider, Egbert Boekema and Wolfgang Helfrich, Journal of the American Chemical Society, 110: 2861-2867 (1988) - empirical demonstration that relevant lipid compounds are capable of self-assembling spontaneously into hollow fibres.
"Living" Under The Challenge Of Information Decay: The Stochastic Corrector Model Versus Hypercycles by Elias Zintzaras, Mauro Santos and Eörs Szathmáry, Journal of Theoretical Biology, 217: 167-181 (2002) - comparison of the viability of two different protocell models, and their ability to withstand deleterious mutations when subject to evolutionary pressures.
Membrane Self-Assembly Processes: Steps Toward The First Cellular Life by Pierre-Alain Monnard and David W. Deamer, The Anatomical Record, 268: 196-207 (2002) - investigation of the viability of lipid vesicles as the outer integument of the first protocells.
Mineral Catalysis And Prebiotic Synthesis: Montmorillonite-Catalysed Formation Of RNA by James P. Ferris, Elements, 1: 145-149 (June 2005) - empirical demonstration of the viability of the RNA world hypothesis, courtesy of the existence of an effiicient means of producing RNA molecules catalytically on montmorillonite clays.
Mineral Surface Directed Membrane Assembly by Martyn M. Hanczyc, Sheref S. Mansy and Jack W. Szostak, Origins of Life and Evolution of Biospheres, 37(1): 67-82 (February 2007) - Another laboratory demonstration that montmorillonite clays can produce lipid vesicles encapsulating RNA molecules under prebiotic cconditions.
Model Of Self-Replicating Cell Capable Of Self-Maintenance by Naoaki Ono and Takashi Ikegami, in Lecture Notes in Computer Science: Advances in Artificial Life, 1674: 399-406 (25th June 1999) (also available as full paper at arXiv.org: adap-org/9905002v2) - mathematical and computer modelling of a hypothetical protocell, demonstrating that such a system would be capable of dynamic maintenance of its outer integument, and would also be capable of a simplified form of cell division.
Molecular Asymmetry In Extraterrestrial Chemistry: Insights From A Pristine Meteorite by Sandra Pizzarello, Yongsong Huang and Marcelo R. Alexandre, Proceeding of the National Academy of Sciences of the USA, 105(10): 3700-3704 (11th March 2008) - determination that moelcular asymmetry (chiral chemistry) occurs naturally, courtesy of the existence of chiral molecules in a meteorite.
Molecular Dynamics Simulation Of The Formation, Structure, And Dynamics Of Small Phospholipid Vesicles by Siewert J. Marrink and Alan E. Mark, Journal of the American Chemical Society, 125: 15233-15242 (2003) - computer modelling of lipd vesicle formation, and comparison of the model with actual experimental results obtained from real lipid vesicle formation, to ensure the robustness of the model.
Molecular Messages by Jack W. Szostak, Nature, 423: 689 (12th June 2003) - review paper covering the question of defining the information content of organic molecules in a rigorous manner.
Montmorillonite Catalysis Of 30-50 Mer Oligonucleotides: Laboratory Demonstration Of Potential Steps In The Origin Of The RNA World by James P. Ferris, Origins of Life and Evolution of the biosphere, 32: 311-332 (2002) - another paper demosntrating the validity of montmorillonite catalysis for prebiotic RNA formation, demonstrating that RNA molecules up to 50 bases long can be formed via this means.
Montmorillonite Catalysis Of RNA Oligomer Formation In Aqueous Solution: A Model For The Prebiotic Formation Of RNA by James P. Ferris and Gözen Ertem, Journal of the American Chemical Society, 115: 12270-12275 (1993) - another paper on montmorillonite catalysis!
Montmorillonite-Catalysed Formation Of RNA Oligomers: The Possible Role Of Catalysis In The Origins Of Life by James P. Ferris, Philosophical Transactions of the Royal Society Part B, 361: 1777-1786 (7th September 2006) - yet another paper demonstrating the validity of montmorillonite catalysis for RNA formation (!)
Nucelotide Synthetase Ribozymes May Have Emerged First In The RNA World by Wentao Ma, Chunwu Yu, Wentao Zhang and Jiming Hu, The RNA Journal, 13: 2012-2019, 18th September 2007 - paper covering a computer simulation aimed at determining the viability of the self-replicating ribozyme hypothesis.
Nutrient Uptake By Protocells: A Liposome Model System by Pierre-Alain Monnard and David W. Deamer, Origins of Life and Evolution of the Biosphere, 31: 147-155 (2001) - laboratory demonstration of the ability of model protocells to acquire nutrients to fuel their chemical processes.
Organic Compounds In Carbonaceous Meteorites by Mark A. Sephton, Natural Products Reports (Royal Society of Chemistry), 19: 292-311 (2002) - a full assay of organic molecules found in various meteorites, including amino acids, sugar-related compounds, pyrimidines and purines (the latter two essential for RNA and DNA formation).
Peptide Formation Mediated By Hydrogen Cyanide Tetramer: A Possible Prebiotic Process by Sherwood Chang, José Flores and Cyril Ponnamperuma, Proceedings of the National Academy of Sciences of the USA, 64(3) 1011-1015 (1st November 1969) - demonstration in the laboratory of another possible peptide formation process that could have taken place on a prebiotic Earth.
Peptide Nucleic Acids Rather Than RNA May Have Been The First Genetic Molecule by Kevin E. Nelson, Matthew Levy and Stanley L. Miller, Proc. Natl, Acad. Sci. USA., 97(8): 3868-3871, 11th April 2000 - demonstration that electric discharge synthesis produces the precursor molecules required to form peptide nucleic acids, which may have been precursors to RNA.
Peptides By Activation Of Amino Acids With CO On (Ni,Fe)S Surfaces: Implications For The Origin Of Life by Claudia Huber and Günter Wächtershäuser, Science, 281: 670-672 (31st July 1998) - demonstration of another peptide formation mechanism relevant to hydrothermal vents, involving vlcanic carbon monoxide and hydrogen sulphide, in combination with nickel and iron compounds in clays.
Phenotypic Diversity And Chaos In A Minimal Cell Model by Andreea Munteanu and Ricard V. Solé, Journal of Theoretical Biology, 240: 434-442 (2006) - computer simulation work aimed at demonstrating the ability of a protocell model to exhibit emergent complexity.
Prebiotic Amino Acids As Asymmetric Catalysts by Sandra Pizzarello and Arthur L. Weber, Science, 303: 1151 (20 February 2004) - empirical demonstration in the laboratory that amino acids can act as asymmetric (chiral) catalysts.
Prebiotic Chemistry And The Origin Of The RNA World by Leslie E. Orgel, Critical Reviews in Biochemistry and Molecular Biology, 39: 99-123 (2004) - review paper covering relevant research into the RNA world hypothesis.
Prebiotic Materials From On And Off The Early Earth by Max Bernstein, Philosophical Transactions of the Royal Society Part B, 361: 1689-1702 (11th September 2006) - determination of the viability of the 'chemical seeding from space' hypothesis for a range of organic molecules.
Prebiotic Synthesis On Minerals: Bridging The Prebiotic And RNA Worlds by James P. Ferris, Biological Bulletin, 196: 311-314 (June 1999) - review paper covering relevant empirical findings supporting the RNA world hypothesis.
Preparation Of Large Monodisperse Vesicles by Ting F. Zhu and Jack W. Szostak, PLoS One, 4(4): e5009 (April 2009) - demonstration of a mechanism for producing lipid vesicles of a range of sizes, which may have prebiotic relevance.
Racemic Amino Acids From The Ultraviolet Photolysis Of Interstellar Ice Analogues by Max P. Bernstein, Jason P. Dworkin, Scott A. Sandford, George W. Copoper and Louis J. Allamandola, Nature, 416: 401-403 - empirical demonstration that amino acids can be synthesised in the conditions extant in deep space, by ultraviolet photolysis of relevant precursor molecules within analogues of cometary ices, by replicating the relevant conditions in the laboratory.
Reconstructing The Emergence Of Cellular Life Through The Synthesis Of Model Protocells by Sheref S. Mansy and Jack W. Szostak, [/i]Cold Spring Harbor Symposia on Quantitative Biology[/i], Volume LXXIV (4th September 2009) - summary of current (as of 2009) experimental progress toward building working model protocells in the laboratory.
Replicating Vesicles As Models Of Primitive Cell Growth And Division by Martin M. Hanczyc and Jack W. Szostak, Current Opinion In Chemical Biology, 8: 660-664 (22nd October 2004) - another paper demonstrating that lipid vesicles can perform a range of mechanical and chemical functions relevant to protocell formation and activity.
Ribosomal Synthesis Of Unnatural Peptides by Kristopher Josephson, Matthew C. T. Hartman and Jack W. Szostak, Journal of the American Chemical Society, 127: 11727-11735 (2005) - empirical demonstration of the reassignments of codons in the genetic code of Escherichia coli to code for amino acids not found in nature, thus demonstrating that the genetic code is not a fixed entity.
Ribozymes: Building The RNA World by Gerald F. Joyce, Current Biology, 6(8): 965-967, 1996 - first steps in the synthesis of RNA ribozymes making possible later research.
RNA Catalysis In Model Protocell Vesicles by Irene A Chen, Kourosh Salehi-Ashtiani and Jack W Szostak, Journal of the American Chemical Society, 127: 13213-13219 (2005) - a documented early empirical attempt to construct model protocells in the laboratory.
RNA-Catalysed Nucleotide Synthesis by Peter J. Unrau and David P. Bartel, Nature, 395: 260-263 (17th September 1998) - development of an RNA molecule that catalyses synthesis of nucleotides for more RNA production, this RNA molecule being produced by in vitro evolution.
RNA-Catalyzed RNA Polymerization: Accurate and General RNA-Templated Primer Extension by Wendy K. Johnston, Peter J. Unrau, Michael S. Lawrence, Margaret E. Glasner and David P. Bartel, Science, 292: 1319-1325, 18th May 2001 - one of the first papers documenting the production of an RNA ribozyme, and demonstration that its replication was high-fidelity, yet imperfect.
RNA-Directed Amino Acid Homochirality by J. Martyn Bailey, FASEB Journal (Federation of American Societies for Experimental Biology), 12: 503-507 (1998) - demonstration of the ability of RNA molecules to perform chiral selection of amino acids.
RNA Evolution And The Origin Of Life by Gerald F. Joyce, Nature, 338: 217-224 (16th March 1989) - review paper covering RNA world hypotheses and extant research.
Selection And Evolution Of Enzymes From A Partially Randomised Non-Catalytic Scaffold by Burckhard Seelig and Jack W. Szostak, Nature, 448: 828-833 (16th August 2007) - demonstration that relevant enyzmatic activity can arise de novo through in vitro evolution of RNA ligases.
Self Replicating Systems by Volker Patzke and Günter von Kiedrowski, ARKIVOC 5: 293-310, 2007 - review paper covering self-replicating chemical systems in general.
Self-Assembling Amphiphilic Molecules Synthesis In Simulated Interstellar/Precometary Ices by Jason P. Dworkin, David W. Deamer, Scott A. Sandford and Louis J. Allamandola, Proceedings of the National Academy of Sciences of the USA, 98(3): 815-819 (30th January 2001) - laboratory demonstration that a range of self-assembling molecules can be synthesised in deep space conditions (cometary ices).
Self-Assembly Of Surfactant-Like Peptides With Variable Glycine Tails To Form Nanotubes And Nanovesicles by Steve Santoso, Wonmuk Hwang, Hyman Hartman and Shuguang Zhang, Nano Letters, 2(7): 687-691 (2002) - laboratory demonstration that certain peptide molecules also self-assemble, this time into tubes and vesicles.
Self-Assembly Processes In The Prebiotic Environment by David Deamer, Sara Singaram, Sudha Rajamani, Vladimir Kompanichenko and Stephen Guggenheim, Philosophical Transactions of the Royal Society Part B, 361: 1689-1702 (11th September 2006) - demonstration of the sort of chemical processes that can take place on clay substrates resulting in self-assembling molecules.
Self-Organising Biochemical Cycles by Leslie E. Orgel, Proceedings of the National Academy of Sciences of the USA, 97(23): 12503-12507 (7th November 2000) - paper reviewing the plausibility of self-organising chemical processes with or without genetic polymers.
Self-Sustained Replication Of An RNA Enzyme by Tracey A. Lincoln and Gerald F. Joyce, ScienceExpress, DOI: 10.1126/science.1167856 (8th January 2009) - another paper on self-replicating RNA enzymes, this time pairs of cross-replicating enzymes.
Semipermeable Lipid Bilayers Exhibit Diastereoselectivity Favouring Ribose by M. G. Sacerdote and Jack W. Szostak, Proceedings of the National Academy of Sciences of the USA, 102(17): 6004-6008 (26th April 2005) - demonstration that lipid bilayers act as chemical filters, exercising selectivity in the molecules transmitted across the boundary.
Sequence- And Regio-Selectivity In The Montmorillonite-Catalysed Synthesis Of RNA by Gözen Ertem and James P. Ferris, Origins of Life and Evolution of the Biosphere, 30: 411-422 (2000) - yet another paper on RNA synthesis by catalysis on montmorillonite!
Shrink-Wrap Vescicles by Shelley M. Fukijawa, Irene A. Chen and Jack W. Szostak, Langmuir: The ACS Journal of Surfaces and Colloids, 21(26): 12124-12129 (20th December 2005) [Note: published online 10th November 2005] - demonstration that lipid vesicles can undergo major size changes and still retain their contents.
Simulation Of The Spontaneous Aggregation Of Phospholipids Into Bilayers by Siewert J. Marrink, Eric Lindahl, Olle Edholm and Alan E. Mark, Journal of the American Chemical Society, 123: 8638-8639 (2001) - generation of a computer model simulating the formation of lipid bilayers, and verification of the robustness of the model, by comparison of its predictions with experimental results from real bilayer formation.
Single-Molecule Imaging Of An In Vitro Evolved RNA Aptamer Reveals Homogeneous Ligand Binding Kinetics by Mark P. Elenko, jack W. Szostak and Antoine M. van Oijen, Journal of the American Chemical Society, 131: 9866-9867 (2009) - production of an RNA atpamer by in vitro evolution, followed by direct examination of its reaction kinetics at the atomic level using fluorescence labelling.
Structural Insights Into The Evolution Of A Non-Biological Protein: Importance Of Surface Residues In Protein Fold Optimisation by Matthew D. Smith, Matthew A. Rosenow, Meitian Wang, James P. Allen, Jack W Szostak and John C. Chaput, PLoS One, 2(5): e467. DOI :10.1371/journal.pone.0000467 - demonstration that protein folding is optimised by surface residues, thus facilitiating a wide range of evolutionary pathways for new protein formation.
Synchronisation Phenomena In Internal Reaction Models Of Protocells by Roberto Serra, Timoteo Carletti, Alessandro Filisetti and Irene Poli, Artificial life, 13: 123-128 (2007)
Synchronisation Phenomena In Protocell Models by Alessandro Filisetti, Roberto Serra, Timoteo Carletti, Irene Poli and Marco Villani, Biophysical Reviews and Letters, 3(1-2): 325-342 (2008)
Synthesis Of 35-40 Mers Of RNA Oligomers From Unblocked Monomers. A Simple Approach To The RNA World by Wenhua Huang and James P. Ferris, Chemical Communications of the Royal Society of Chemistry, 1458-1459 (2003)
Synthesis Of Activated Pyrimidine Ribonucleotides In Prebiotically Plausible Conditions by Matthew W. Powner, Béatrice Gerland and John D. Sutherland, [i]Nature, 459:239-242 (14th May 2009)
Synthesis Of Long Prebiotic Oligomers On Mineral Surfaces by James P. Ferris, Aubrey R. Hill Jr, Rihe Liu and Leslie E. Orgel, Nature, 381: 59-61 (2nd May 1996)
Synthesising Life by Jack W. Szostak, David P. Bartel and P. Luigi Luisi, Nature, 409: 387-390 (18th January 2001)
Synthetic Protocell Biology: From Reproduction To Computation by Ricard V. Solé, Andreea Munteanu, Carlos Rodriguez-Caso and Javier Macia, Philosophical Transactions of the Royal Society Part B, 362: 1727-1739 (October 2007)
Systems Chemistry On Early Earth by Jack W. Szostak, Nature, 459: 171 (14th May 2009)
Template-Directed Synthesis Of A Genetic Polymer In A Model Protocell by Sheref S. Mansy, Jason P. Schrum, Mathangi Krisnamurthy, Sylvia Tobé, Douglas A. Treco and Jack W. Szostak, Nature, 454: 122-125 (4th June 2008)
The Antiquity Of RNA-Based Evolution by Gerald F. Joyce, Nature, 418: 214-221, 11th July 2002
The Case For An Ancestral Genetic System Involving Simple Analogues Of The Nucleotides by Gerald F. Joyce, Alan W. Schwartz, Stanley L. Miller and Leslie E. Orgel, Proceedings of the National Academy of Sciences of the USA, 84: 4398-4402 (July 1987)
The Descent of Polymerisation by Matthew Levy and Andrew D. Ellington, Nature Structural Biology, 8(7): 580-582, July 2001
The Emergence Of Competition Between Model Protocells by Irene A Chen, Richard W. Roberts and Jack W. Szostak, Science, 305:1474-1476 (3rd September 2004)
The Generality Of DNA-Templated Synthesis As A Basis For Evolving Non-Natural Small Molecules by Zev J. Gartner and David R. Liu, Journal of the American Chemical Society, 123: 6961-6963 (2001)
The Lifetimes Of Nitriles (CN) And Acids (COOH) During Ultraviolet Photolysis And Their Survival In Space by Max P. Bernstein, Samantha F. M. Ashbourne, Scott A. Sandford and Louis J. Allamandola, The Astrophysical Journal, 601: 3650270 (20th January 2004)
The Lipid World by Daniel Segré, Dafna Ben-Eli, David W. Deamer and Doron Lancet, Origins of Life And Evolution of the Biosphere, 31: 119-145, 2001
The Miller Volcanic Spark Discharge Experiment by Adam P. Johnson, H. James Cleaves., Jason D. Dworkin, Daniel P. Glavin, Antonio Lazcano and Jeffrey L. Bada, Science, 322: 404 (17th October 2008)
The Origin And Early Evolution Of Life: Prebiotic Chemistry, The Pre-RNA World, And Time by Antonio Laczano and Stanley R. Miller, Cell, 85: 793-798 (14th June 1996)
The Origin And Emergence Of Life Under Impact Bombardment by Charles S. Cockell, Philosophical Transactions of the Royal Society Part B, 361: 1845-1856 (7th September 2006)
The Origin Of Replicators And Reproducers by Eörs Szathmáry, Philosophical Transactions of the Royal Society Part B, 361: 1689-1702 (11th September 2006)
The Prebiotic Molecules Observed In The Interstellar Gas by P. Thaddeus, Philosophical Transactions of the Royal Society Part B, 361: 1689-1702 (7th September 2006)
The Roads To And From The RNA World by Jason P. Dworkin, Antonio Lazcano and Stanley L. Miller, Journal of Theoretical Biology, 222: 127-134 (2003)
The Stability Of The RNA Bases: Implications For The Origins Of Life by Matthew Levy and Stanley R. Miller, Proceedings of the National Academy of Sciences of the USA, 95: 7933-7938 (July 1998)
Thermostability Of Model Protocell Membranes by Sheref S. Mansy and Jack W. Szostak, Proceedings of the National Academy of Sciences of the USA, 105(36): 13351-13355 (9th September 2008)
Toward Synthesis Of A Minimal Cell by Anthony C. Forster and George M. Church, Molecular Systems Biology (2006) doi:10.1038/msb4100090
Transcription And Translation In An RNA World by William R. Taylor, Philosophical Transactions of the Royal Society Part B, 361: 1689-1702 (11th September 2006)
Two Step Potentially Prebiotic Synthesis Of α-D-Cystidine-5'-Phosphate From D-Glyceraldehyde-3-Phosphate by Carole Anastasi, Michael A. Crowe and John D. Sutherland, Journal of the American Chemical Society (Communications), 129: 24-24 (2007)
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