I always thought that enjoyable experience was the most sensible axiom for a life philosophy, but there is an interesting problem:

If there were a device which somehow simulated perfect pleasure for you, or even just a large amount of constant pleasure, would you choose that device, or this life?

Note that consequences of using the device (such as inconveniencing people having to support you, or grief due to your absence) are not part of this thought experiment; this scenario is concerned with establishing a coherent life philosophy.