 Originally Posted by tommo
Interesting. It has also been linked to dopamine as well. Which does make sense, because basically you get more dopamine than you really should from certain things, which means you get addicted to doing them.
Although those receptors are closely linked really (in ways I don't really understand). So it could easily be both.
I do know that when I smoke weed I basically forget about most of my OCD things though.
Stuff relating to germs I actually have to remind myself to do it, otherwise I'll be all anxious when I come down.
As opposed to when sober I basically can't get it off my mind if I don't do it.
That makes perfect sense, actually. :O 5-HT2A receptors in the nucleus accumbens, the major motivational center of the brain, have been implicated in a lot of the local dopamine release in response to rewarding stimuli, even including things like cocaine, amphetamine, and morphine, and psychedelics, of course. I think they might have linked it to alcohol too, but I can't remember right off the top of my head.... 5-HT2A also forms functional heterodimers with D2, the main dopamine receptor implicated in psychosis and schizophrenia. At these sites activating one receptor increases activity of the other, so it's possible that altered and enhanced 5-HT2A activity could be generating some of the psychosis-like symptoms of OCD through this mechanism as well. I also wonder about its role in intrusive sexual thoughts (which are, or were if you count the fact that they don't really bother me anymore, my most severe symptom), as D2 is also a major player in libido, and it could explain at least for me why so many of my sexual fantasies are so psychedelic and why all of my psychedelic trips are so sexual. I also think that D2 plays an important role in perception of entities, especially with drugs like salvia, and I get entities a lot more easily than all of my friends as well.... Hmmmm....
Anyway, about weed, it helps me as well but only if it's because it's made me totally couch-locked and zoned out, or just really distracted with something. When I start paying attention to it while high it can get much worse, however it follows the same pattern while sober so it's not surprising, I think the weed just makes me get even more worked into it if I let myself get that far. I think it used to help more, but it's been too long to say now... once you start tripping a good amount your high tends to change to feel more psychedelic because you notice the tripping sensations more easily, sometimes in ways that don't really ever seem to go back to how they were, or at least take a very, very long time to do so. (Word to the wise.) I think that probably helps me obsess more because I get those racing mindsets more easily. Actually, with this new polymorphism information I wouldn't be surprised if it's helped me notice the psychedelic aspects of my mind in general more, too.... (It's certainly felt like it has.)
The good thing about 5-HT2A/D2 anxiety though is that it isn't real. If you ignore it, it goes away, just like letting a trip do its thing instead of freaking out about an ego death. The same can definitely be said of OCD symptoms... if you don't let them bother you then they're really not that big of a deal, in my opinion anyway. Maybe if you have it REALLY bad, but most people don't, and if you do have it that bad you should probably be using medication anyway.... To leave on a potentially interesting note, I must point out the fact that SSRIs attenuate both OCD symptoms and the effects of psychedelics, as well. 
 Originally Posted by Linkzelda
When I was getting close to going into the dream state, all of that "noise" stuff like feeling the bottom of my feet warping, I hate when I try to think of something I could do, just before the WILD becomes a success, that it's always a bad image that shows up like....
-Dropping into planets....(No that's scary!!!)
-Being probed by aliens...(No, wrong hole buddy!)
-Or just randomly being in a huge body of water, and wondering if some big ass creature will show up...(I know it would be a dream, but if something like this shows up, I would poop my pants).
I always hated encountering that thing in windwaker when I DIDN'T have a Boomerang, Arrows, or even a freaking Hookshot....that was scary stuff not knowing where I would be transported to if I got too close to the Big Octo...
.......and what was even scarier than that was that Cyclos guy who would float on a cloud, and have a big ass cyclone surrounding him...and because it covered a wider span than the Big Octos' whirlpool, if you got caught, all I could say was,
or even Gohma:
I love Windwaker and I would be so stoked if any of those things happened to me in a dream, sounds like an adventure. X)
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