 Originally Posted by Zhaylin
I hope work went well, Aly. Have you tried eye drops? Sitting in front of the computer causes a lot of people to blink less which dries out your eyes. I don't know if that would contribute to a headache though lol Getting outside and into the fresh air is always best though (so says the gal who never sees the light of day unless driving somewhere  )
I haven't, but I really should. You'd think I'd have some Visine lol. Well, I might.... I've never bought it myself but my parents gave me some for Christmas once. >___> I'm not sure where it went though.... But that probably would help. Maybe.... I have this weird blinking compulsion that comes and goes and it's been up lately and that's probably messing with it too. Sometimes I just need to blink because it feels like my eyes dry out so fast. <_____<
Me ---> 
I really should give that a shot! And I know what you mean... I've been like that lately lol. I'm usually either at home, a friend's place, or downtown at the middle of the night. I am getting to see more of the world with my pizza delivery routes though. 
 Originally Posted by tommo
I recently read about the 20-20-20 rule, which is basically every 20 minutes, look at something at least 20 feet away (can be clouds or mountains or anything) for 20 seconds. Apparently that relaxes your eye muscles and stops eye strain.
I've heard something similar to that before, but not with all the 20s.... That definitely makes it seem easier to work with than just remembering to do something like that every now and then. I might have to set some alarms or something to remind myself!
 Originally Posted by tommo
Ah, ok, I thought that may have been what you meant....
Nope, I was actually looking a while ago for Ketamine analogues, but I didn't find much IIRC. Except for PCP, but.... nope nope nope.
Why are you interested in the kappa opioid action?
It seems to me the NMDA antagonism is what causes it's unbelievable effects. Coincidentally (since you were talking about headaches)
I was reading John Lilly's book on floatation tanks and he said he once used it in combination with Ketamine IM, and he basically visualised
his migraines as a ball of energy or something and he pushed it out of his head, and the migraine was gone, but it kept coming back in.
He told his assistant to give more injections and eventually after 3 doses I think, the ball got infinitely far away and vanished from sight,
and he never got another migraine again. He thought he'd have to re-dose eventually, but he never did.
I've read some insane things like that about Ketamine, and IIRC it is hypothesised that it's NMDA activity is somehow responsible for
it's almost brain-resetting effects - cure addiction, depression, anxiety, OCD, intense chronic pain etc.
That's really interesting... though it doesn't surprise me. I have to wonder if he could have gotten rid of the migraines by doing that even without the ketamine though. Ketamine is certainly hypnotic so it may have been more just like a push to make it an easier process....
In middle school my parents bought me this book that was a beginner's guide to hypnosis. It wasn't anything too complex, or at least that I could fully grasp or feel motivated enough to dedicate myself to at the time, but there were some sample scripts in there with advice on what words to change here and there for each individual case, so I did use those. I tried to put a lot of my family and friends under trances for therapeutic reasons. (Most of them just said they felt great afterward, but at least one friend noticed immediate results. As did we... because he was suddenly reading all the time like I suggested, which was really uncharacteristic of him lol.) At the beginning of the book, before any of those scripts, there was an anecdote about one day when his friend's kid (or some kid he knew at least... it's been a long time now obviously) had his really bad earache that was clearly causing him a lot of stress. I may be slightly off on this again just because it was so long ago, but it's enough to get my point across.... It was something like, he put his hand over the kid's ear and told the kid to strongly visualize looking into his own ear, traveling down into it, and then looking back out. He asked the kid if it was dark in his ear and he said yes, and then he told the kid to imagine it becoming light. As he did he took his hand away, and told the kid to open his eyes. When he did the earache was gone, and he ran off happily.
Not long after I read that, I was walking through the halls during class at school (for some reason that escapes me now... probably just using the bathroom or something) and a friend of mine walked by. He had been in gymnastics for years so he was leaving school early to go to train for something I think, but he told me that he had a really bad earache that was bringing him down. I jumped at the opportunity and asked him if I could try something, so I did exactly as the book said. And it worked! He suddenly looked really happy and said it was gone, and then thanked me and we parted ways. I felt pretty awesome. Hehe, but so the point is of course that both this and John Lilly's migraine thing are undoubtedly working on the same process here, if you ask me, and the earache one didn't even require any prep. Granted, migraines are worse than earaches, and who knows how permanent the earache technique would be (though you could just know how to do it again from that point on), but it's because of this that I'm naturally inclined to be skeptical. It's a cool outcome for sure, but how can we be sure that it was really the ketamine that did it, rather than just facilitating it by enhancing visualization?
I don't doubt that ketamine's NMDA antagonism plays some role in it's effects, but I don't think it necessarily accounts for nearly all of it. Ketamine does lots of things, and human tests done with it shouldn't really be able to claim just NMDA as the important receptor. It may have been implicated in all those things you said, but what about its other receptors? For addiction, the kappa opioid receptor has been linked to helping that more than the NMDA receptor has. Salvinorin A in particular in particular been shown to have antiaddictive effects, and it's presumably because of the way that the kappa receptors modulate dopamine transporters in the reward pathways. It's also said to cause antidepressant and antianxiety effects through an interaction between kappa opioid and CB1 receptors. A mix of NMDA and kappa opioid activity is also what's thought to play a role in ibogaine's antiaddictive effects. But the kappa receptors interest me most specifically because of how certain kappa antagonists have a cascade effect that activates c-Jun N-terminal kinase and causes a sustained antagonism of the overall kappa effect that is unrelated to ligand binding. All of the drugs that do this cause rapid antidepressant effects that last weeks. It really makes me wonder, because coming down from a salvia trip can actually feel pretty good, and that's a commonly reported effect. I wonder if the same outcome can occur from kappa downregulation, sort of like a kappa crash? If it did then the effect would be sustained even when the receptors balanced themselves out. That one's just a thought of course, but it's what first made me really interested in them.... I also wonder if it's related to the psychedelic afterglow you can get after a strong cannabinoid trip, since the dynorphin release is so high at that point. I've read that dynorphins are important in integrating fear memory; wouldn't it be neat if the process of facing your fears in a trip, finally starting to overcome then, and then having a period of integrating them in your life afterward was simply the realization of the process of kappa activation, slow deactivation and then downregulation, and then the resulting JNK activation? After all, even 5-HT2A receptors are said to lose a significant part of their effect without CB1 activation, and since they release 2-AG, a full agonist, they could cause the same dynorphin release at some point....
Anyway.... There's also the fact that ketamine is a nicotinic acetylcholine antagonist. Those have been shown to have rapid antidepressant effects due to fast upregulation of those nicotinic receptors, and even scopolamine is said to have antidepressant effects because of that. And like scopolamine, it's even a muscarinic acetylcholine antagonist too (<--- why ketamine is one of the best drugs by the way). Anticholinergics have been known to help OCD symptoms, and to have antianxiety effects in low doses (and very high doses). Mu opioid receptors have as well, and though ketamine's mu activation is not the strongest, it's still worth mentioning. Oh, and that reminds me, sigma receptors sometimes have antidepressant effects as well, and I know ketamine hits them at some point.... The chronic pain I'll give you though lol. The NMDA antagonism probably is doing quite a lot of that, though it also says something about nitric oxide synthase on Wikipedia....
I'm not trying to say that ketamine isn't great for all those things, but I just hesitate to put it all on NMDA antagonism. Nearly every NMDA antagonist hits a very wide range of receptor types, and your mindset at the time of the experience really does make a difference too. I think hallucinogens tend to bring things out of us more often than actually cause them to happy personally, they make you realize things that you're capable of.
So I guess what I'm really trying to say is... I think it's really just ketamine in its entirey that's awesome, and it helps you by showing you how awesome you already are lol. But I am particularly interested in those kappa opioid receptors, because I've always thought salvia could be good for all sorts of stuff like that if it wasn't so dysphoric. But ketamine overcomes that with everything else it does. I just wish they would publish more information on how those kappa antagonists work, because I'd really like to read more about the JNK stuff. It's really interesting.
 Originally Posted by tommo
Anonymous browsing does mean a lot, the people who got caught were morons, including DPR. He posted his goddamn e-mail address with his real name when he was advertising the site in the early stages - Idiot.
The few people who got caught pales in comparison to the number who get caught buying elsewhere, and those people were also ordering gigantic amounts to their home addresses, and dealing.
Again - Idiots.
With RC's, I think you'd have to be nuts to use them lol
They aren't tested, they're manufactured in China in makeshift labs with horrible/no quality control and there are constant reports of people getting the wrong substances sent to them.
You're also using the clear web, which means your IP address is easily obtained and any cop could arrest you if they so feel like it.
Sure Silk Road was public, but you're still hidden, as long as you don't use your home address to send stuff to.
Well, dealing them is inherently going to come with risk. In just buying for personal use, I would much rather use a basic RC site than the Silk Road - mainly because, as I said, they're still quasi-legal. If they really want to get you, they'll get you eventually. It doesn't really matter whether or not you get stuff sent to your home.... All they have to do is wait for you to show up where it's getting sent and then follow you home. So what I figure is, are they more likely to get the person who's buying LSD or the person who's buying something that might be considered questionable because it's sort of similar to LSD? And at least the RC sites don't have Wikipedia pages dedicated to them; becoming a public spotlight pushes the limits of hiding in plain sight. The guy was stupid though too, for sure lol.
And hey man, they were all research chemicals once. LSD, MDMA, ketamine.... And who says the quality of those drugs has to be any better than those Chinese labs? Reports of people getting the wrong substances happen every day, and they do it on purpose. At least the RC suppliers are really trying to give you the exact drug you asked for at the exact dosage you asked for, at least the good ones. We're all aware of the bromo-dragonFLY incident too, and accidents do happen, but that could just as easily have happened with blotters, and probably has before.
And honestly, I would just rather risk it than not experience them. I always got my RCs through people who bought them to deal, so I knew they had already been tested at that point. And there's some great chemicals out there, man.... You wouldn't even want to try something like DPT or 2C-E or 4-HO-MiPT?
 Originally Posted by tommo
MDMA is scarce here, it gets better every now and again, but the quality is still crap in general.
Ketamine I would have no idea where to get, but maybe you're right, the same person could prob get that as well, since she can get pills.
I dunno.... I worry about purity too much, don't wanna get some bunk crap that kills me lol That's why I've held off on MDMA for so long even though I can easily get it.
I feel ya man, but I mean, you have to take some risk lol. That's pretty much how doing drugs goes, unless you stick to things you get legally like morning glories, cacti, or Ayahuasca, or weed or mushrooms since you can't really be fooled there (unless the guy who hunted the mushrooms wasn't very smart about it >_>). Which doesn't sound that bad now that I say it... but still, there's other cool stuff too. >w<
With MDMA, you really don't have a choice. Just get molly if you can and learn how to identify it, or if you get pills then never take more than one on the first try. That's Harm Reduction 101. No one's going to sell you something that can kill with one dose. The worst you'll get is a bad trip.
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Rant/Rave: I've been so busy for the last couple of days!! But today's finally my first day off for the week. I'm going to be out of the house for a lot of the day but at least I don't have any real responsibilities. And tonight I should just be chilling at home. It's going to be a good day.
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