Alyzarin

Hey, I have heard of rauwolscine! In particular I have heard it recommended as an alternative to yohimbine for those that get too much anxiety and side effects from taking actual yohimbine. (The context was rauwolscine's alpha receptor antagonism and its use for fat loss in already-lean individuals.) I know it's easy to overdo things on yohimbine and become very anxious, but I don't know as much about rauwolscine's side effects.

I am very interested in what you've got cooking here! You are thinking about using it before bed rather than as a WBTB type of deal? I know that Yuschak recommended yohimbine for high levels of reasoning and dream control. Are you going for the same thing or looking for a different set of effects?

I followed this up with a peanut butter and jelly sandwich, potato chips, and two trefoil cookies. (Girl scout cookies!

Hey, we just got our Girl Scout cookies today. No rauwolscine, but I'm still excited.

Woah, that's rare! I wasn't expecting anyone to know what it was. I used to peruse fitness supplement forums every now and then, it's a hidden goldmine of drug information. I'm not fit enough to justify actually using this stuff for exercise, but I'm always trying to seek out new uses for things. I have taken things for the heck of it before though, and I am familiar with yohimbine. Rauwolscine is certainly less physical by comparison. Yohimbine made me anxious easily even before I really had anxiety, back when I could take large doses of amphetamine and be fine. It's a nasty drug, if you ask me.

I was intending on trying the rauwolscine before bed, just because I never do WBTBs anyway. The main issue is that a big part of the reason I don't do them is because once I'm up, I'm pretty much up. I've tried to do WBTBs many times and failed, and adding a stimulant into the mix doesn't give me a whole lot of confidence as far as increasing my chances of falling asleep again goes. Do you know what Yuschak recommends for yohimbine, though? I'd be willing to consider it if taking it before bed isn't going to be very effective anyway.

Here's the deal with yohimbine vs rauwolscine. As far as I'm concerned, from a pharmacological standpoint, yohimbine is just shy of being perfect, but it has a major drawback. Due to blocking adrenergic autoreceptors, it causes a stimulation of the prefrontal cortex by increasing the release of catecholamines and acetylcholine and enhances REM phases while dampening most other sleep phases. That alone sounds GREAT. The problem? Well, aside from the fact that it's physically stimulating, yohimbine also blocks dopamine receptors, especially D2. That means that it actually weakens the generation of the dream world at its core. That by itself is enough to earn a permanent ban from my catalog of dream supplements, because I want all the D2 I can get (both asleep AND awake!). Believe me, I used to chase out the drugs that had D2 activity because they're like invariably the best by far. Raulwoscine, on the other hand... lacks dopamine receptor affinity. Its stimulation is also mental much more than physical, but otherwise it keeps roughly the same effects as yohimbine because it mostly shares the other receptor sites. This includes the prefrontal stimulation and changes in sleep phases. See where I'm going with this?

Hey, we just got our Girl Scout cookies today. No rauwolscine, but I'm still excited.

Nice! Enjoy them, we're already on the second wave because the first was gone so quickly.

Yeah, Yuschak remarked on how controversial yohimbine is as a supplement. Since he said it was really easy to get insomnia from it, he didn't recommend it as a primary trigger but more to be used in small quantities to get improved vividness and recall. He says that he uses 1/25th (!!) of a 9 mg pill in order to get the desired effect. (How do you even do that?) He's combining that with some galantamine + choline trigger, as usual, so it's just there to enhance the experience.

He tied the positive effects of yohimbine to higher catecholamine levels, in particular noradrenline. Perhaps his recommended dose is small enough that the D2 effects won't be too bad...?

Yuschak warned of overflow occurring at pretty modest levels of yohimbine. Basically, high levels of noradrenaline crossing the blood-brain barrier and arousing your fight-or-flight response. And since it's yohimbine, arousing other stuff as well, I guess. But it doesn't seem like you suffered anything too much like this, so you may be good to go!

I've heard you speak with great affection about D2 many times! It's so cool that you can pick out what receptors are being tickled by any given experience!

Anyway, I'm looking forward to hearing how all of this goes!

1/25th of a pill!? That's like... art. How can you be sure you've even taking anything? ...Well, it's possible that he avoided the D2 antagonism at that level, but I don't see myself chopping a pill that precisely any time soon, sooo....

That's the thing too, though. Like I said, yohimbine is a physical stimulant, and it causes anxiety because it does have that fight-or-flight response. Rauwolscine doesn't. I think it's easy to see which one would be preferable!

I'll probably try this pretty soon, it's just something I want to be really careful with. I know very little about it, after all. More caution is always good when dealing with a plant chemical instead of something like a vitamin or amino acid.

Oh, if you tried enough D2 drugs I think you would be able to pick it out, too.... Though I say that, but from what I can tell I may actually be somewhat sensitive to it. It's undeniable to me. It's basically like... it forces me into a state of pure, transcendental, sexual bliss, fills my imagination with endless corresponding psychedelic chaos, drives my mind's processing power to its maximum capacity so that concepts like "infinity" and "perfection" are entirely commonplace, and then forces the generation of the dream world... and since all of those other things are my state of mind - just as how dream control works because whatever your mind renders is what the dream world is - it's exactly those things that my reality becomes.

I could go on so much more about that... but I have to go to a family birthday party now lol. Perhaps another time!